Principal IT Systems Engineer

Company: Regeneron Pharmaceuticals, Inc.
Location: Troy
Posted on: March 3, 2026

Job Description:

We are seeking a highly skilled and proactive Principal IT Systems Engineer to join our dynamic team, reporting directly to the Services Delivery Manager for Performance, Alerting, & Observability. The role will play a critical role in maintaining the reliability, uptime, availability, and performance of our IOPS IT server and infrastructure environments, as well as managing compliance solutions. This position is instrumental in ensuring the stability and operational efficiency of our IT infrastructure while strictly adhering to Good Manufacturing Practice (GMP) standards. As a Principal IT Systems Engineer, a typical day might include the following: Proactively monitor and maintain Windows Server environments to guarantee efficient performance and reliability. Configure and manage virtualized environments, including virtual machines, storage, and networking, to meet evolving business needs. Identify and resolve issues in a timely manner, ensuring high availability, security, and resilience of network resources. Conduct detailed root cause analysis and implement corrective actions to prevent recurrence, improving system reliability. Develop and maintain comprehensive documentation of processes, procedures, and best practices to facilitate knowledge sharing and training. Ensure rigorous compliance with GMP standards across all relevant processes and systems. Implement and manage robust change control processes to uphold system integrity and compliance. Collaborate with security teams to ensure IAM systems and infrastructure align with organizational security policies and frameworks. This Role May Be for You If You Have: A unique blend of IT operations expertise and system engineering, with a robust background in Windows Servers, Virtualization, Cloud platforms (AWS & Oracle), and Security Operations Demonstrated experience with: SailPoint for identity governance and lifecycle management. CyberArk for privileged access management. Ivanti for exposure management. Nexthink for visibility and control over employee experience Axonious for overall environment visibility. High Performance Computing (HPC) for complex problem solving. Familiarity with PowerShell, Python, or Bash scripting. Virtualization technologies and cloud platforms, including virtual machine management and configuration. In order to be considered for this position, you must hold a BA/BS degree in Computer Science or related field and Principal IT Systems Engineer: 8 years of relevant experience with data center technologies (VMware, NetApp, Dell EMC storage), backup solutions, and IT and Security operations. Staff IT Systems Engineer: 10 ears of relevant experience with data center technologies (VMware, NetApp, Dell EMC storage), backup solutions, and IT and Security operations. 3-5 years of experience in system administration, network engineering, or a related role desired. Experience working in GMP environments and ensuring compliance with relevant standards preferred. Relevant certifications (e.g., MCSE, VCP, CCNA, SailPoint, CyberArk) are a plus. Preferred knowledge of understanding of IT compliance guidelines, including PICS, CFR21 Part 11, Annex 11, and GAMP. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries specific benefits, please speak to your recruiter. Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regenerons roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regenerons on-site policy and expectations for your role and your location. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $92,200.00 - $176,000.00

Keywords: Regeneron Pharmaceuticals, Inc., Leominster , Principal IT Systems Engineer, IT / Software / Systems , Troy, Massachusetts